abstract：:Techniques for sentinel lymph node injections have varied over the years in both cervical and uterine malignancy lymph node mapping. There remains considerable variation in techniques, particularly for uterine malignancies. This review summarizes some of the techniques that have been published and are currently utiliz...

journal_title：Gynecologic oncology

authors： Abu-Rustum NR,Khoury-Collado F,Gemignani ML

更新日期：2008-11-01 00:00:00

abstract：:Non-healing wounds represent a significant cause of morbidity and mortality for a large portion of the adult population. Wounds that fail to heal are entrapped in a self-sustaining cycle of chronic inflammation leading to the destruction of the extracellular matrix. Among cancer patients, malnutrition, radiation, phys...

journal_title：Gynecologic oncology

authors： Menke MN,Menke NB,Boardman CH,Diegelmann RF

更新日期：2008-11-01 00:00:00

abstract：OBJECTIVES:To estimate healthcare resource utilization and costs of cervical, vulvar and vaginal cancers in a large U.S. health plan. METHODS:We estimated incremental ambulatory visits, hospitalizations, prescription fills and healthcare costs for cancer cases relative to population controls. Data for cervical (n=2788...

journal_title：Gynecologic oncology

authors： Insinga RP,Ye X,Singhal PK,Carides GW

更新日期：2008-11-01 00:00:00

abstract：OBJECTIVE:To compare the oncologic outcomes of women who underwent a fertility-sparing radical trachelectomy (RT) to those who underwent a radical hysterectomy (RH) for stage IB1 cervical carcinoma. METHODS:We performed a case-control study of all patients with stage IB1 cervical carcinoma who underwent a vaginal or a...

journal_title：Gynecologic oncology

authors： Diaz JP,Sonoda Y,Leitao MM,Zivanovic O,Brown CL,Chi DS,Barakat RR,Abu-Rustum NR

更新日期：2008-11-01 00:00:00

abstract：:The radical hysterectomy is often associated with severe bladder dysfunction and colorectal motility disorders. These issues may arise as a result of damage incurred to the motor and sensory autonomic nerve supply, both of sympathetic and parasympathetic origin, that innervate the uterus, vagina, urinary bladder, and ...

journal_title：Gynecologic oncology

authors： Fujii S

更新日期：2008-11-01 00:00:00

abstract：OBJECTIVES:While there are many psychosocial interventions for cancer patients, few are brief in nature. The aim of this study was to investigate the usefulness of a single-visit psychosocial intervention for gynecologic cancer patients. METHODS:One hundred women attending a gynecologic cancer clinic as new patients w...

journal_title：Gynecologic oncology

authors： Powell CB,Kneier A,Chen LM,Rubin M,Kronewetter C,Levine E

更新日期：2008-10-01 00:00:00

abstract：OBJECTIVE:Serous borderline ovarian tumors (SBOT) are slow growing, noninvasive ovarian epithelial neoplasms, which tend to recur as low-grade invasive carcinomas (LGC) with a much worse prognosis. We investigated the molecular basis of this progression. METHODS:We established cultures of three SBOTs and one LGC from ...

journal_title：Gynecologic oncology

authors： Woo MM,Salamanca CM,Symowicz J,Stack MS,Miller DM,Leung PC,Gilks CB,Auersperg N

更新日期：2008-10-01 00:00:00

abstract：OBJECTIVE:The aim of this study is to investigate whether the presence of endometriosis is a prognostic factor in patients diagnosed with clear cell carcinoma (CCC) of the ovary. METHODS:Retrospective chart review was performed to all patients diagnosed with CCC and endometriosis between 1975 and 2002. All pathology r...

journal_title：Gynecologic oncology

authors： Orezzoli JP,Russell AH,Oliva E,Del Carmen MG,Eichhorn J,Fuller AF

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVE:We demonstrate the feasibility of implementing a referral and management system for cryotherapy-ineligible women in a "screen-and-treat" cervical cancer prevention program targeting HIV-infected women in Zambia. METHODS:We established criteria for patient referral, developed a training program for loop elect...

journal_title：Gynecologic oncology

authors： Pfaendler KS,Mwanahamuntu MH,Sahasrabuddhe VV,Mudenda V,Stringer JS,Parham GP

更新日期：2008-09-01 00:00:00

abstract：:A population-based survey (AFRODITA Study) was conducted in Spain in order to estimate the coverage and factors associated with cervical cancer cytological screening. The results of this survey indicate that the rate of screening for cervical cancer in Spain is 75.6% in women between 18 and 65 years. This high rate of...

journal_title：Gynecologic oncology

authors： Puig-Tintoré LM,Torné A,Alonso I

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVE:Younger patients with invasive epithelial ovarian cancer (EOC) frequently want to preserve their fertility, but the role of fertility-sparing surgery in EOC has not been well defined. We therefore assessed tumor recurrence, patient survival and pregnancy outcomes in patients with invasive EOC who underwent fe...

journal_title：Gynecologic oncology

authors： Park JY,Kim DY,Suh DS,Kim JH,Kim YM,Kim YT,Nam JH

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVES:Lymph node status is an important prognostic factor in patients with squamous cell carcinoma (SCC) of the vulva. Complete inguinofemoral lymph node dissection (ILND) is accompanied by a high morbidity. Sentinel lymph node biopsy (SLNB) was established for less invasive lymph node (LN) staging. The aim of thi...

journal_title：Gynecologic oncology

authors： Johann S,Klaeser B,Krause T,Mueller MD

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVE:To evaluate the usefulness of pre-operative serum CA-125 in the management of women diagnosed with uterine papillary serous carcinoma (UPSC). We hypothesized that elevated pre-operative levels of serum CA-125 correlate with higher disease stage and poorer prognosis. METHODS:Patients diagnosed with UPSC and m...

journal_title：Gynecologic oncology

authors： Olawaiye AB,Rauh-Hain JA,Withiam-Leitch M,Rueda B,Goodman A,del Carmen MG

更新日期：2008-09-01 00:00:00

abstract：:Effective cytotoxic treatment options for advanced cervical cancer are exceedingly limited. Cisplatin-based combination chemotherapy, the most commonly used cytotoxic therapy, has produced response rates ranging from 20% to 30% and overall survival of less than 10 months. Because of the minimal degree of success with ...

journal_title：Gynecologic oncology

authors： del Campo JM,Prat A,Gil-Moreno A,Pérez J,Parera M

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVE:Determine the safety and efficacy of cetuximab plus paclitaxel and carboplatin as initial treatment of stage III/IV ovarian cancer. METHODS:An initial intravenous [IV] dose of cetuximab (400 mg/m(2)) was administered over 120 min followed by weekly IV infusions of cetuximab (250 mg/m(2)) administered over 60...

journal_title：Gynecologic oncology

authors： Konner J,Schilder RJ,DeRosa FA,Gerst SR,Tew WP,Sabbatini PJ,Hensley ML,Spriggs DR,Aghajanian CA

更新日期：2008-08-01 00:00:00

abstract：OBJECTIVES:In the present study (EDiTH III study), the genotype-specific prevalence of HPV in low-grade squamous intraepithelial lesions (LSIL) was estimated to predict the potential benefit of HPV vaccination in France. This prevalence was compared to that previously reported in France in high-grade cervical intraepit...

journal_title：Gynecologic oncology

authors： Prétet JL,Jacquard AC,Saunier M,Clavel C,Dachez R,Gondry J,Pradat P,Soubeyrand B,Leocmach Y,Mougin C,Riethmuller D,EDiTH study group.

更新日期：2008-08-01 00:00:00

abstract：OBJECTIVES:CD4(+)CD25(+) regulatory T-cells (Tregs), that express the transcription factor FOXP3, suppress effector T-cell populations and can enable tumour cells to evade the host immune response. In this study, we investigated the numbers of FOXP3(+) Tregs in the normal and malignat endometrium and examined potential...

journal_title：Gynecologic oncology

authors： Giatromanolaki A,Bates GJ,Koukourakis MI,Sivridis E,Gatter KC,Harris AL,Banham AH

更新日期：2008-08-01 00:00:00

abstract：OBJECTIVES:Most ovarian cancer patients are diagnosed at an advanced stage (67%) and prospects for significant improvement in survival reside in early diagnosis. While expression patterns of a recently identified biomarker family, microRNA, appear to be characteristic of tumor type and developmental origin, microRNA pr...

journal_title：Gynecologic oncology

authors： Taylor DD,Gercel-Taylor C

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVES:The objectives of this phase II trial were to assess the activity and tolerability of the combination of bevacizumab and erlotinib in patients with recurrent ovarian, primary peritoneal or fallopian tube cancer. METHODS:This was a single arm, multicenter phase II trial with overall objective response as the...

journal_title：Gynecologic oncology

authors： Nimeiri HS,Oza AM,Morgan RJ,Friberg G,Kasza K,Faoro L,Salgia R,Stadler WM,Vokes EE,Fleming GF,Chicago Phase II Consortium.,PMH Phase II Consortium.,California Phase II Consortium.

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVE:Bilateral oophorectomy (BOE) is often recommended in order to prevent cancer at hysterectomy for non-malignant diseases and when familial risk of ovarian and breast cancer has been identified. Surgical menopause increases the risk of cardiovascular mortality, however, the intervening mechanisms are not clear....

journal_title：Gynecologic oncology

authors： Dørum A,Tonstad S,Liavaag AH,Michelsen TM,Hildrum B,Dahl AA

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVES:Fixed-dose rate gemcitabine plus docetaxel is active as second-line therapy for metastatic uterine leiomyosarcoma. We sought to determine the activity of this regimen as first-line treatment. METHODS:Eligible women with advanced uterine leiomyosarcoma were treated with gemcitabine 900 mg/m(2) over 90 min, o...

journal_title：Gynecologic oncology

authors： Hensley ML,Blessing JA,Mannel R,Rose PG

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:The incidence of postoperative delirium (PD) in the elderly ranges between 3-60% but has never been examined in gynecologic oncology. Our goal was to identify pre, intra, and postoperative risk factors associated with the development of PD. METHODS:English speaking women of 60 years and above undergoing maj...

journal_title：Gynecologic oncology

authors： McAlpine JN,Hodgson EJ,Abramowitz S,Richman SM,Su Y,Kelly MG,Luther M,Baker L,Zelterman D,Rutherford TJ,Schwartz PE

更新日期：2008-05-01 00:00:00

abstract：OBJECTIVE:To evaluate the clinical accuracy and clinical impact of positron emission tomography (PET) or positron emission tomography/computed tomography (PET/CT) in detecting and treating tumor recurrence in patients with treated uterine sarcoma. METHODS:Results of 36 patients who underwent PET or PET/CT in post-ther...

journal_title：Gynecologic oncology

authors： Park JY,Kim EN,Kim DY,Suh DS,Kim JH,Kim YM,Kim YT,Nam JH

更新日期：2008-05-01 00:00:00

abstract：OBJECTIVE:To investigate the influence of human anti-mouse antibodies (HAMA) on serial CA 125 measurements in serum of patients with epithelial ovarian cancer following single intraperitoneal (IP) therapy with Yttrium-90-labeled human milk fat globule 1 murine monoclonal antibody ((90)Y-muHMFG1) as part of a large inte...

journal_title：Gynecologic oncology

authors： Oei AL,Sweep FC,Massuger LF,Olthaar AJ,Thomas CM

更新日期：2008-05-01 00:00:00

abstract：OBJECTIVES:The purpose of this study was to retrospectively evaluate the technique, feasibility and oncological safety of laparoscopic radical hysterectomy with vaginectomy and reconstruction of vagina in patients with stage I primary vaginal carcinomas. METHODS:Between February 2003 and July 2004, four patients, that...

journal_title：Gynecologic oncology

authors： Ling B,Gao Z,Sun M,Sun F,Zhang A,Zhao W,Hu W

更新日期：2008-04-01 00:00:00

abstract：OBJECTIVE:Previous data demonstrate an association between cyclooxygenase activity and development of cervical cancer. This review investigates the role of cyclooxygenase-2 (COX-2) in the development of cervical cancer and potential therapeutic options targeting this pathway. METHODS:A literature search was conducted ...

journal_title：Gynecologic oncology

authors： Young JL,Jazaeri AA,Darus CJ,Modesitt SC

更新日期：2008-04-01 00:00:00

abstract：OBJECTIVES:We previously reported a 10% rate of catheter complications, including inflow obstruction and infection, using a fenestrated catheter to administer intraperitoneal (i.p.) chemotherapy for ovarian cancer. Because of recent reports of higher rates of catheter complications, we performed this study to update ou...

journal_title：Gynecologic oncology

authors： Black D,Levine DA,Nicoll L,Chou JF,Iasonos A,Brown CL,Sonoda Y,Chi DS,Leitao MM,Abu-Rustum NR,Ferguson SE,Barakat RR

更新日期：2008-04-01 00:00:00

abstract：OBJECTIVE:Reduced Selenium-Binding Protein 1 (SELENBP1) expression was recently shown in multiple cancers. There is little information on the expression and function of SELENBP1 in cancer progression. In order to develop a better understanding of the role of SELENBP1 in ovarian cancer, our objective was to determine if...

journal_title：Gynecologic oncology

authors： Stammer K,Edassery SL,Barua A,Bitterman P,Bahr JM,Hales DB,Luborsky JL

更新日期：2008-04-01 00:00:00

abstract：:Advances in surgery and chemotherapy have improved the 5-year survival for patients with epithelial ovarian cancer, but have not impacted on the ultimate rate of cure in a disease that is diagnosed in late stage and that recurs in the majority of patients. "Omic" technologies promise to define genetically driven aberr...

journal_title：Gynecologic oncology

authors： Ashworth A,Balkwill F,Bast RC,Berek JS,Kaye A,Boyd JA,Mills G,Weinstein JN,Woolley K,Workman P

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVE:In advanced ovarian cancer, patients cytoreduced to no visible disease appear to have improved survival compared to patients with visible residual tumor < or = 10 mm. It remains unresolved whether this is due to better chemotherapy response and/or simply "re-setting the clock," such that patients with less re...

journal_title：Gynecologic oncology

authors： Eisenhauer EL,Abu-Rustum NR,Sonoda Y,Aghajanian C,Barakat RR,Chi DS

更新日期：2008-02-01 00:00:00

abstract：OBJECTIVE:To evaluate the predictive value of conventional criteria for identifying surgically unresectable disease among patients with ovarian cancer undergoing initial operative intervention at tertiary referral centers employing a so-called aggressive approach to surgical cytoreduction. METHODS:All patients with ad...

journal_title：Gynecologic oncology

authors： Salani R,Axtell A,Gerardi M,Holschneider C,Bristow RE

更新日期：2008-02-01 00:00:00

abstract：OBJECTIVES:To evaluate the role of LPA in regulating E-cadherin cell surface expression, adhesion, and invasion in epithelial ovarian carcinoma (EOC) cells. METHODS:E-cadherin mRNA expression in OVCA429 and IOSE-29 cells was evaluated by real-time RT-PCR. Immunofluorescence and Western blot analysis were performed to ...

journal_title：Gynecologic oncology

authors： Gil OD,Lee C,Ariztia EV,Wang FQ,Smith PJ,Hope JM,Fishman DA

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:Several cytokines have been associated with immune regulation and prognosis in ovarian cancer. CD4+CD25+ Tregs and CD3+CD56+ NK-like T cells are involved in the immune response against the tumor. We have investigated the association of cytokines in the ascites from patients with ovarian cancer with these pop...

journal_title：Gynecologic oncology

authors： Bamias A,Koutsoukou V,Terpos E,Tsiatas ML,Liakos C,Tsitsilonis O,Rodolakis A,Voulgaris Z,Vlahos G,Papageorgiou T,Papatheodoridis G,Archimandritis A,Antsaklis A,Dimopoulos MA

更新日期：2008-02-01 00:00:00

abstract：INTRODUCTION:Focused ultrasound under real-time MR guidance and control (MRgFUS) can be used for the thermal ablation of tissue. Currently this technique is used clinically for the noninvasive treatment of uterine leiomyomas and is in clinical evaluation for breast cancer, adenomyosis and other indications. MRgFUS is b...

journal_title：Gynecologic oncology

authors： Machtinger R,Inbar Y,Ben-Baruch G,Korach J,Rabinovici J

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:Protease-activated receptor-2 (PAR-2) is a G-protein-coupled receptor that is cleaved and activated by trypsin and tryptase. There is evidence that PAR-2 contributes to tumor progression in stomach, colon, pancreas, prostate and breast cancer patients. However, the role of PAR-2 in cervical cancer is still un...

journal_title：Gynecologic oncology

authors： Sánchez-Hernández PE,Ramirez-Dueñas MG,Albarran-Somoza B,García-Iglesias T,del Toro-Arreola A,Franco-Topete R,Daneri-Navarro A

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVES:This phase II study conducted to investigate the efficacy and toxicity of the combination of gemcitabine (GEM) and pegylated liposomal doxorubicin (LDOX) alternating with cisplatin (CDDP) and cyclophosphamide (CTX) in platinum-resistant/refractory, paclitaxel pretreated epithelial ovarian cancer (EOC). PATI...

journal_title：Gynecologic oncology

authors： Pectasides D,Xiros N,Papaxoinis G,Aravantinos G,Sykiotis C,Pectasides E,Psyrri A,Koumarianou A,Gaglia A,Gouveris P,Economopoulos T

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Hec1 (Highly Expressed in Cancer gene 1) has recently been shown to play an important role in the proper segregation of chromosomes during mitosis. Recently, an adenovirus delivery system carrying RNA interference (RNAi) of Hec1 has been reported in a cervical adenocarcinoma model. Adenoviral delivery system...

journal_title：Gynecologic oncology

authors： Numnum TM,Makhija S,Lu B,Wang M,Rivera A,Stoff-Khalili M,Alvarez RD,Zhu ZB,Curiel DT

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:Oncolytic adenoviruses capable of replication selectively in tumor cells are an appealing approach for the treatment of neoplastic diseases refractory to conventional therapies. The aim of this study was to evaluate the effect of dose and scheduling of a tropism-modified, adenovirus serotype 3 receptor-target...

journal_title：Gynecologic oncology

authors： Raki M,Särkioja M,Desmond RA,Chen DT,Bützow R,Hemminki A,Kanerva A

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVES:The aim of this prospective study was to evaluate the impact of integrated PET-CT on treatment management in ovarian carcinoma recurrence suspicion because of increased CA-125. METHODS:Twenty-nine patients (mean age=61 years), initially treated for ovarian carcinoma (FIGO stage I n=2, stage II n=3, stage II...

journal_title：Gynecologic oncology

authors： Soussan M,Wartski M,Cherel P,Fourme E,Goupil A,Le Stanc E,Callet N,Alexandre J,Pecking AP,Alberini JL

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:Epidemiologic data suggest that aberrant androgen homeostasis may promote aggressive epithelial ovarian cancer biology. Hyperandrogenism results from both obesity and expression of polymorphic androgen receptor (AR) allelotypes harboring short cytosine-adenine-guanine (CAG) repeat sequences; both have been sh...

journal_title：Gynecologic oncology

authors： Li AJ,Elmore RG,Pavelka JC,Karlan BY

更新日期：2007-12-01 00:00:00